Natasha Dias5th Year PhD Candidate
Bayer School of Natural and Environmental Sciences
Selcer Lab, Mellon Hall
Education:M.S. Biotechnology, Bangalore University (India), 2006
B.S. Microbiology, Pune University (India), 2004
Characterizing steroid sulfatase activity and gene expression in MG-63 preosteoblast cell line.
Estrogen plays an important role in regulation of bone turnover by inhibiting osteoclastic bone resorption. Postmenopausal women have low estrogen production, but inactive sulfated steroids, particularly estrone sulfate and dehydroepiandrosterone sulfate, are present at considerable levels in peripheral circulation. Conversion of these precursors to active estrogens may help maintain bone density in postmenopausal women. The enzyme steroid sulfatase converts sulfated steroids into their active form in peripheral tissues. Steroid sulfatase is known to occur in bone, but little is known about the regulation of this enzyme. Through my research I am investigating the activity and expression of steroid sulfatase during differentiation in the human preosteoblastic cell line (MG-63).