Jelena Janjic

July 2009–Present
Associate Professor of Pharmaceutics (Tenured 2015)
School of Pharmacy and Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA

• Mentor and train students (PhD, MS, PharmD, undergraduate) in drug formulation design, molecular imaging, nanotechnology and pharmaceutics in a laboratory setting
• Direct MS/PhD research theses
• Design and synthesize novel drug delivery and imaging agents
• Innovative approaches to theranostic medicine design from nanocolloids to semisolid dosage forms
• Design of novel in vitro and in vivo pharmacological tests for nanomedicines in small and large animal models of trauma, neuromusculoskeletal diseases and organ transplantation.
• Design, development and manufacturing process design for:
  • Pain nanomedicines (inventor of the first inflammatory pain nanomedicine)
  • Nanomedicine and biomaterials for Vascularized Composite Allotransplantation (VCA): molecular imaging and immune cell tracking in rejection, immunomodulation, local drug delivery and tissue/organ preservation)
  • Nanomedicine and biomaterials in regenerative medicine.

May 2011–Present
Founder and Co-Director
Chronic Pain Research Consortium (CPRC), Duquesne University, Pittsburgh PA

The CPRC takes an integrated and multidisciplinary approach to the study of all aspects of chronic pain. . Consortium members are faculty across the Duquesne University campus, representing expertise in neuroscience, biology, pharmacy, nursing, physical therapy, molecular biology, biochemistry, medicinal chemistry, neuropharmacology, molecular imaging, and psychology.  Consortium has to date obtained more than 6 million dollars in external funding for research and education with members serving as PIs and/or Co-Is. CPRC held 5 research retreats, regular bimonthly journal club since 2012, and hosted several distinguished speakers in the field. The Consortium has become a locally and nationally recognized group for interdisciplinary and holistic research of pain and chronic pain in varied disciplines, from neuroscience, to education and nanotechnology. It continues to foster and support projects with unique partnerships between health practitioners and scientists.

July 2018–March 2021
ORISE Faculty Fellow, Principal Scientist
AIRMED/RESTOR Program, 59th Medical Wing United States Airforce, USAISR, San Antonio, TX

• Advise, mentor and train surgical residents and medical fellows at the USAISR
• Direct research on design and development of nanomedicine for the medical needs of the warfighter and their families
• Post-trauma and surgical pain therapeutic development
• Nanomedicine applied to post-surgical care, transplantation and organ preservation in combat casualty care scenarios
• Coordinate collaborative research between AIRMED program and academic groups.

May 2014–Present
Faculty Member
McGowan Research Institute for Regenerative Medicine, Pittsburgh, PA

• Nanotechnology, drug delivery and imaging systems development applied to regenerative medicine.
• Inflammation and pain therapeutic and diagnostic strategies in regeneration, transplantation and surgical recovery.
• Monitoring/treatment of rejection with nanotechnology and localized immunosupression delivery systems.

July 2009–June 2015
Assistant Professor of Pharmaceutics
School of Pharmacy and Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA

July 2009–December 2011
Visiting Scientist
Department of Biological Sciences, Carnegie Mellon University, Pittsburgh PA

• Formulate and assess in vitro multimodal biosensor /19F MRI reagents for tracking therapeutic cells and immunotherapy

October 2008–July 2009
Director of Pharmaceutical Chemistry
Celsense Inc., Pittsburgh, PA

• Designed, synthesized and formulated the first Phase I clinical 19F MRI reagent for monitoring immunotherapeutic cells in humans
• Designed and formulated preclinical grade 19F MRI reagents for quantification of inflammation
• Transferred technology from academic to industrial laboratories
• Coordinated team efforts in producing MRI reagents for pre-clinical and clinical use
• Coordinated team efforts in analytical chemistry development for evaluating MRI reagents
• Consulted on biological in vitro assay development for testing MRI reagents
• Trained formulation scientists in microfluidization nanoreagent production

2006–2008
Senior Research Scientist
Celsense Inc., Pittsburgh, PA

• Designed, synthesized, formulated and biologically evaluated novel MRI reagents
• Designed and formulated several novel MRI reagents currently under development towards commercialization
• Developed analytical assay for MRI reagents
• Processed data and evaluated protocol for scale up, analysis and follow up of novel MRI reagents produced in industrial setting
• Trained research biologists in evaluation of MRI reagents

2006–2009
Research Biologist
Department of Biological Sciences, Carnegie Mellon University, Pittsburgh PA

• Designed, synthesized and formulated novel in vivo MRI contrast reagents and tracers for in vivo cell tracking
• Designed, synthesized and formulated the first dual fluorescence/19F MRI reagents
• Developed assays for in vitro evaluation of MRI tracers (19F NMR, cell based assays, fluorescence imaging, biochemical techniques, confocal microscopy)
• Coordinated and/or directed grant writing, project development, and research efforts of graduate students, staff and external collaborators

2005–2006
Research Associate
The Scripps Research Institute, Jupiter, FL      

• Developed HTS cell-based assays for large compound, DNA and RNA collection screens targeting cancer and inflammation pathways
• Screened focused small molecule libraries (>1000 members)
• Screened focused DNA library (>1000 members)

2002–2005
Research/Teaching Fellow
University of Pittsburgh School of Pharmacy, Pittsburgh, PA    

• Conducted microwave chemistry
• Conducted medicinal chemistry (small molecule synthesis, analog design, SAR, protein-ligand interactions, computational modeling)
• Conducted cell-based assays (cell-based screening studies, luminescence assays, protein expression, cell transformation via plasmid transfection)
• Conducted fluorescence-polarization assays for in vitro drug screening
• Trained undergraduate researchers in microwave chemistry, cell-based assays and data analysis

2000–2001
Research Specialist
University of Pittsburgh Cancer Institute, Pittsburgh, PA          

• Conducted flow cytometry, ELISA, western blot and cell culture cytoxicity assays
• Conducted cancer cell biology research

1999–2000
Pharmacist
Pharmacy “Labud”, Belgrade, SR Yugoslavia

• Compounded pharmaceutical and cosmetic preparations
• Developed cosmetics products
• Retail pharmacy and patient counseling

1998–1999
Pharmacist Administrator
National Reserves of Republic of Serbia, SR Yugoslavia          

• Managed medical supplies, prescription and over-the-counter medications in the national reserves

 

Awards

2023	Dean’s Award, School of Pharmacy, Duquesne University, Pittsburgh, PA
2020	President’s Award of Excellence in Scholarship, Duquesne University, Pittsburgh, PA
2020	Carnegie Science Award in Life Sciences, Honorable Mention, Pittsburgh, PA
2019	Defense Tech Connect Innovator Award Challenge, October 8, 2019, National Harbor, Washington DC
2018	Pittsburgh Business Times 2018 Innovator Award
2018	Duquesne University Research Hall of Fame Inductee
2018	Faculty Award, School of Pharmacy, Duquesne University, for excellence in teaching, scholarship and service
2018	Nominee, President's Award of Excellence in Service to the Mission of Duquesne University, by the School of Pharmacy, Duquesne University
2018	Selected to represent Duquesne University at 2018 Collegium at the College of the Holy Cross, June 2018
2013	Faculty Member of The Rho Chi Society, The Academic Honor Society in Pharmacy
2013	Wakonse Fellow, selected by the Duquesne University Center of Teaching Excellence to present at and attend Wakonse Teaching Conference
2004	Graduate Student Excellence Award, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA
2004	National Medicinal Chemistry Symposia Travel Award, Madison, WI
2001	JHF-CORO Health Sciences Fellowship, Pittsburgh, PA

 

Recognition in Public Media

2022	“Why are some painkillers less effective in females?” Medical News Today
2022	“New Study Highlights Differences in Neuropathic Pain Relief for Men and Women” Duquesne University Times
2021	“Nanotechnology May Help Improve Organ Transplantation Outcomes” Duquesne University Times and McGowan Institute newsletter
2020	Article in the Pittsburgh Post Gazette: Created particle could cure chronic pain https://www.post-gazette.com/news/health/2020/06/18/Created-particle-could-cure-chronic-pain/stories/202006110130
2020	Article in the Duquesne Times: “Researcher Helps Lead Nanomedicine Effort in Transplantation”
2019	TEDxCMU Invited Speaker for "Ripple Effect" Main Conference, March 30, 2019
2019	Article in Duquesne Times on USAF Visit
2018	Duquesne times article on Innovator 2018 Award
2018	Interview with Joe Palca, NPR
2018	Highlights From the American Pain Society Scientific Summit: Can Nanomedicine Play a Role in the Future of Pain Treatment? A session at the March 4-6, 2018, event featured animal studies on macrophage-targeted nanomedicine by Ashley Cowie on 29 May 2018
2018	Interview for WTAE (Channel 4 News)
2018	"Duquesne Researchers Working On Drug That Could Be Upgrade To Current Anti-Inflammatories" by Joaquin Gonzalez • April 3, 2018 NPR, WESA interview
2017	Interview for the podcast Regenerative Medicine Today - Janjic - Podcast #167
2014	"Duquesne Professors Collaborate To Pioneer Research On Chronic Pain" September 23rd, 2014 Duquesne University Magazine, Fall 2014
2014	"Where Does It Hurt? New Processes Development by Duquesne's Chronic Pain Consortium Could Provide the Answer" April 16, 2014, Duquesne University News
2014	"Got Collaboration? New Provost Award Encourages Interdisciplinary Research" Duquesne University Times April 9, 2014
2012	"Grant Funds Chronic Pain Study at Duquesne University", Duquesne University News, February 1, 2012
2012	"University Researchers Collaborate to Study Chronic Pain" in The Chronicle, a quarterly newsletter published by American Chronic Pain Association, March 2012
2011	"Personalizing Nanomedicine", front page featured full article by Lauren K. Wolf , Chemical and Engineering News, 89 (39), pp 29-32, September 26, 2011
2004	Pittsburgh Tribune Review Newsmaker, August 22, 2004
2003	"Winning Combination", full feature article by Kris B. Mamula, PITT Magazine, Summer Issue
2003	"Combinatorial Libraries: Life's Tinker Toys" by By Gail Dutton in The Scientist May 9, 2003

Peer Reviewed Publications

(*Corresponding author; Chronologically ordered from most recent; ORCID: https://orcid.org/0000-0002-0539-8359; Scopus H index  = 21;  Google Scholar H index = 25)

1. B Deal, K Phillips, C Crelli, JM Janjic*, JA Pollock “RNA-Seq Reveals Sex Differences in Gene Expression during Peripheral Neuropathic Inflammation and in Pain Relief from a COX-2 Inhibiting Theranostic Nanoemulsion” International Journal of Molecular Sciences 2023, 24 (11), 9163   (IF: 6.208)
2. M Herneisey and JM Janjic* “Multiple Linear Regression Predictive Modeling of Colloidal and Fluorescence Stability of Theranostic Perfluorocarbon Nanoemulsions” Pharmaceutics 2023, 15 (4), 1103  (IF:6.525)
3. Deal, L. Raynolds, C. Patterson, J.M. Janjic and J. A. Pollock* “Behavioral and inflammatory sex differences revealed by celecoxib nanotherapeutic treatment of peripheral neuroinflammation” Scientific Reports 2022, 12, 8472 (IF:4.997)
4. Vichare and J. M. Janjic* “Macrophage-Targeted Nanomedicines for ARDS/ALI: Promise and Potential” Inflammation 2022, 45 (6), 2124-2141
5. M Balogh, JM Janjic*, AJ Shepherd* “Targeting Neuroimmune Interactions in Diabetic Neuropathy with Nanomedicine” Antioxidants & redox signaling 2022, 36 (1-3), 122-143 (invited review article) (IF:6.6)
   
6. Charaschanya, T.S. Maskrey, M.G. LaPorte, J.M. Janjic*, and P.Wipf* “Synthesis and Optimization of Nitroxide-Based Inhibitors of Ferroptotic Cell Death in Cancer Cells and Macrophages” ACS Medicinal Chemistry Letters 2022, 13 (3), 403-408 (IF:4.632)
7. JM Nichols, CV Crelli, L Liu, HV Pham, JM Janjic*, AJ Shepherd* “Tracking macrophages in diabetic neuropathy with two-color nanoemulsions for near-infrared fluorescent imaging and microscopy” Journal of Neuroinflammation (2021), Vo. 18, Article number: 299   (IF: 9.3)
8. SKR Adena, M. Herneisey, E. Pierce, PR Hartmeier, S. Adlakha, MA Hosfeld, JK Drennen, JM Janjic* “Quality by Design Methodology Applied to Process Optimization and Scale up of Curcumin Nanoemulsions Produced by Catastrophic Phase Inversion” Pharmaceutics, 2021, Vol 13(6), 880 (IF:6.525)
9. E.Lambert and J.M. Janjic* “Quality by design approach identifies critical parameters driving oxygen delivery performance in vitro for perfluorocarbon based artificial oxygen carriers” Scientific Reports 2021, 11, Article number: 5569  (IF:4.997)  
10. M Herneisey, PF Salcedo, T Domenech, C Bagia, SS George, R Tunney, S. Velankar, T.K. Hitchens, J.M. Janjic* “Design of thermoresponsive polyamine cross-linked perfluoropolyether hydrogels for imaging and delivery applications” ACS Medicinal Chemistry Letters 2020 (10^th Anniversary Special Edition, invited manuscript); Vol. 11, 10, 2032–2040  (IF:4.632)
11. Stevens, M. Saleem, B. Deal, J.M. Janjic, J.A. Pollock.* "Targeted COX-2 inhibiting nanomedicine results in pain-relief and differential expression of the RNA transcriptome in the dorsal root ganglia of injured male rats". Molecular Pain, 2020 Volume 16: 1–19 (IF:3.37)
12. L Liu, H Karagoz, M Herneisey, F Zor, T Komatsu, S Loftus, BM Janjic, VS Gorantla and JM Janjic* “Sex Differences Revealed in a Mouse CFA Inflammation Model with Macrophage Targeted Nanotheranostics” Theranostics 2020, 10 (4), 1694 (IF:12.4)
13. F Zor, H Karagoz, H Kapucu, Y Kulahci, JM Janjic, VS Gorantla* “Immunological considerations and concerns as pertinent to whole eye transplantation” Current opinion in organ transplantation 2019, 24 (6), 726-732
14. Stevens AM, Liu L, Bertovich D, Janjic JM, Pollock JA*. Differential Expression of Neuroinflammatory mRNAs in the Rat Sciatic Nerve Following Chronic Constriction Injury and Pain-Relieving Nanoemulsion NSAID Delivery to Infiltrating Macrophages. Int J Mol Sci. 2019 Oct 24;20(21). pii: E5269. doi: 10.3390/ijms20215269.
15. JM Janjic* and VS Gorantla “Nanomedicine: new hope for transplant paradigms lost?” Nanomedicine 2019, 14 (20), 2645-2649: Foreword to Special Issue “Nanomedicine in Organ  Transplantation  and  Regenerative Surgery –Advances,  Applications,  and Future Directions” Nanomedicine, November, 2019, Co-Edited by. V.S. Gorantla and J.M. Janjic
16. Lambert, V. Gorantla, J.M. Janjic* “Pharmaceutical Design and Development of Perfluorocarbon Nanocolloids for Oxygen Delivery in Regenerative Medicine” Nanomedicine 2019, Published Online:28 Oct 2019https://doi.org/10.2217/nnm-2019-0260 Part of Special Issue “Nanomedicinein Organ Transplantation  and  Regenerative Surgery –Advances,  Applications,  and Future Directions” Nanomedicine, November, 2019, Co-Edited by. V.S. Gorantla and J.M. Janjic
17. M Saleem, B Deal, E. Nehl, JM Janjic, JA Pollock* “Nanomedicine-driven neuropathic pain relief in a rat model is associated with macrophage polaritry and mast cell activation.” Acta Neuropathol Commun. 2019. 7, Article number: 108
18. Herneisey, E.Lambert, A. Kachel, E. Shychuck, J. K. Drennen III and J.M. Janjic* “Quality by Design Approach Using Multiple Linear and Logistic Regression Modeling Enables Microemulsion Scale Up” Molecules 2019, 24(11), 2066; https://doi.org/10.3390/molecules24112066
19. M Saleem, AM Stevens, B Deal, L Liu, J Janjic, JA Pollock* “A New Best Practice for Validating Tail Vein Injections in Rat with Near-infrared-Labeled Agents.” Journal of visualized experiments: JoVE 2019 (146), e59295, doi:10.3791/59295
20. M. Janjic “Inflammation Targeted Nanomedicine: A perspective on the promise and potential of biomedical technologies for pain diagnosis and management.” (Invited Article) Practical Pain Management 2019, Vol (19), Issue 1, pages: 33-35
21. Lambert, J.M. Janjic* “Multiple Linear Regression Applied to Predicting Droplet Size of Complex Perfluorocarbon Nanoemulsions for Biomedical Applications” Pharmaceutical Development and Technology 2019, 24, 700-710
22. Herneisey¶, L. Liu¶, E. Lambert, N. Schmitz, S. Loftus, and J.M. Janjic* Development of Theranostic Perfluorocarbon Nanoemulsions as a Model Non-Opioid Pain Nanomedicine Using a Quality by Design (QbD) Approach AAPS PharmSciTech 2019, 20: 65. https://doi.org/10.1208/s12249-018-1287-6
23. M. Janjic* and V.S. Gorantla* “Novel Nanoimaging Strategies for Noninvasive Graft Monitoring in Vascularized Composite Allotransplantation” invited commentary, Current Transplantation Reports 2018, 5 (4), 369-372 https://doi.org/10.1007/s40472-018-0221-x
24. M. Janjic*, K. Vasudeva, M. Saleem, L. Liu, S.K. Patel, A. Stevens, J.A. Pollock* “Low-dose NSAIDs reduce pain via macrophage targeted nanoemulsion delivery to neuroinflammation of the sciatic nerve in Rat” Journal of Neuroimmunology 2018, http://www.jni-journal.com/article/S0165-5728(18)30012-2/fulltext (The first Theranostic Pain Nanomedicine)
25. M. Janjic* and V. Gorantla "Clinically translatable nanotheranostic platforms for peripheral nerve regeneration: design with outcome in mind", Proc. SPIE 10508, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications X, 1050803 (20 February 2018); doi: 10.1117/12.2289288; https://doi.org/10.1117/12.2289288
26. M. Janjic* and V. Gorantla “Peripheral Nerve Nano-Imaging: Monitoring Treatment and Regeneration” 2017, AAPS J. Sep;19(5), 1304-1316 (invited review)
27. Herneisey, M., Williams, J., Mirtic, J., Liu, L., Potdar, S., Bagia, C., Cavanaugh, J.E., Janjic, J.M.* Development and characterization of resveratrol nanoemulsions carrying dual-imaging agents Therapeutic Delivery 2016, 7 (12), 795-808
28. BJ Kolber, JM Janjic, JA Pollock, KJ Tidgewell Summer undergraduate research: A new pipeline for pain clinical practice and research BMC Medical Education 2016 (1), 16:135 DOI: 10.1186/s12909-016-0648-7
29. Janjic, J.M.*, Berlec, A., Bagia, C., Liu, L.S., Jeric, I., Gach, M., Janjic, B.M., Strukelj, B.NIR and MR imaging supported hydrogel based delivery system for anti-TNF alpha probiotic therapy of IBD (2016) Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 9723, art. no. 972309
30. Liu, L., Bagia, C., Janjic, J.M.* “The First Scale up Production of Theranostic Nanoemulsions” Bioresearch Open Access 2015, 4(1): 218-228. (Invited Paper)
31. Patel, S.K., Beaino, W., Anderson, C.J., Janjic, J.M.* Theranostic Nanoemulsions for Macrophage COX-2 Inhibition in a Murine Inflammation Model Clinical Immunology 2015, 160, 59-70.
32. S.K. Patel and J.M. Janjic* “Macrophage Targeted Theranostics as Personalized Nanomedicine Strategies for Inflammatory Diseases” Theranostics 2015, (2), 150
33. Vasudeva, K., Vodovotz, Y., Azhar, N., Barclay, D., Janjic, J.M., Pollock, J.A.* “In Vivo and Systems Biology Studies Implicate IL-18 as a Central Mediator in Chronic Pain” Journal of Neuroimmunology 2015, 283, 43-49
34. Wen, Y.,  Liu, W., Bagia,  C.,  Zhang, S., Bai,  M.,  Janjic, J.M.,  Giannoukakis, N., Gawalt, E. S., Meng, W.S.* “Antibody-Functionalized Peptidic Membranes for Neutralization of Allogeneic Skin Antigen-Presenting Cells” Acta Biomaterialia 2014, 10 (11), 4759-4767
35. Jia, N., Zhang, S., Shao, P., Bagia, C., Janjic, J.M., Ding, Y. and Bai, M.* “Cannabinoid CB2 Receptor as a New Phototherapy Target for Inhibition of Tumor Growth.” Molecular Pharmaceutics 2014, 11 (6), 1919–1929
36. Janjic, J.M.*, Shao, P., Zhang, S., Yang, X., Patel, S.K., Bai, M.* “Perfluorocarbon nanoemulsions with fluorescent, colloidal and magnetic properties” Biomaterials 2014, 35 (18), 4958-4968
37. Mountain, G.A., Jelier, B.J.,  Bagia, C., Friesen, C.M.,  Janjic, J.M. * “Design and formulation of nanoemulsions using 2-(poly (hexafluoropropylene oxide)) perfluoropropyl benzene in combination with linear perfluoro (polyethylene glycol dimethyl ether)”Journal of Fluorine Chemistry 2014, 162, 38–44
    
38. Vasudeva, K. Andersen, B. Zeyzus-Johns, T.K. Hitchens, S.K. Patel, A. Balducci, J.M. Janjic, J. A. Pollock* “Imaging Neuroinflammation In Vivo in a Neuropathic Pain Rat Model with Near-Infrared Fluorescence and 19F Magnetic Resonance” PloS one 2014, 9 (2), e90589
39. M.J. Patrick^¥, J.M. Janjic^¥, H. Teng, M.R. O'Hear, C.W. Brown, J.A. Stokum,  B.F. Schmidt, E.T. Ahrens*, A.S. Waggoner “Intracellular pH measurements using perfluorocarbon nanoemulsions” Journal of the American Chemical Society 2013, 135 (49), 18445-18457. (^¥Co-first authors)
40. S.K. Patel, J. Williams, J.M. Janjic* “Cell labeling for ¹⁹F MRI: New and Improved Approach to Perfluorocarbon Nanoemulsion Design” Biosensors 2013, 3(3), 341-359 (open access)
41. S.K. Patel, M.J. Patrick, J.A. Pollock, J.M. Janjic* “Two-color fluorescent (near-infrared and visible) triphasic perfluorocarbon nanoemulsions” Journal of Biomedical Optics 2013, 18 (10), 101312,
42. J.M. Janjic*, S.K. Patel, M.J. Patrick, J.A. Pollock, E. DiVito, M. Cascio “Suppressing inflammation from inside out with novel NIR visible perfluorocarbon nanotheranostics”  (Invited Paper) Progress in Biomedical Optics and Imaging - Proceedings of SPIE 2013, 8596, art. no. 85960L 
43. S.K. Patel, Y. Zhang, J.A. Pollock, J.M. Janjic* "Cyclooxygenase-2 Inhibiting Perfluoropoly (ethylene glycol) ether Theranostic Nanoemulsions - In Vitro Study" PloS one 2013, 8(2):e55802.
44. Balducci, Y. Wen, Y. Zhang, B.M. Helfer, T.K. Hitchens, W.S. Meng, A.K. Wesa, J.M. Janjic*, "A novel probe for the non-invasive detection of tumor-associated inflammation" Oncoimmunology 2013, 2 (2), e23034
45. C.E. O’Hanlon, K.G. Amede, M.R. O’Hear, J.M. Janjic* “NIR-labeled perfluoropolyether nanoemulsions for drug delivery and imaging” Journal of Fluorine Chemistry 2012, 137, 27–33
46. T.K. Hitchens, Q. Ye, D.F. Eytan, J.M. Janjic, E.T. Ahrens,  C. Ho “¹⁹F MRI detection of acute allograft rejection with in vivo perfluorocarbon labeling of immune cells” Magnetic Resonance in Medicine 2011, 65, 1144-1153
47. D.K.K. Kadayakkara, J.M. Janjic, L.K. Pusateri, W.B. Young, E.T. Ahrens "In vivo observation of intracellular oximetry in perfluorocarbon-labeled glioma cells and chemotherapeutic response in the CNS using fluorine-19 MRI" Magnetic Resonance in Medicine 2010, 64,1252-1259               
    
48. Helfer, A. Balducci, A. Nelson, J.M. Janjic, R.R. Gil, P. Kalinski, J. M. de Vries, E.T. Ahrens, R. Mailliard, “Functional assessment of human dendritic cells labeled for in vivo ¹⁹F MRI cell tracking” Cytotherapy 2010, 12, 238-250.
49. D.K.K. Kadayakkara, P. Beatty, J.M. Janjic, M. Turner, E. Ahrens, O. Finn “Inflammation driven overexpression of the hypoglycosylated abnormal MUC1 links inflammatory bowel disease (IBD) and pancreatitis” Pancreas 2010, 39, 510-515
    
50. Srinivas, M.S. Turner, J.M. Janjic, P.A. Morel, D.H. Laidlaw, E.T. Ahrens “In vivo cytometry of antigen specific T-cells using 19F MRI” Magnetic Resonance in Medicine 2009, 62, 747-753
51. J.M. Janjic, E.T. Ahrens “Fluorine-containing nanospheres for MRI” Advanced Reviews, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, Sept./Oct. 2009, 1, 492-501, invited by editors
52. J.M. Janjic, M. Srinivas, D.K.K. Kadayakkara, E.T. Ahrens “Self-delivering nanoemulsions for dual fluorine-19 MRI and fluorescence detection”, Journal of American Chemical Society 2008, 130, 2832-2413. (highly cited paper, cited >200 times)
53. Sarachine, M.J.; Janjic, J.M.; Wipf, P; Day, B.W. “Biphenyl C-cyclopropylalkylamides as new scaffolds for targeting estrogen receptor β” Bioorganic Medicinal Chemistry Letters 2009, 19, 2404-2408.
54. Wipf, P.; Gong, H.; Janjic, J.M.; Li, S.; Day, B.W.; Xie, W. “New Opportunities for pregnane X receptor (PXR) targeting in drug development. Lessons from enantio- and species-specific PXR ligands identified from a discovery library of amino acid analogues” Mini Reviews Medicinal Chemistry 2007, 7, 617-625
55. Wipf, P.; Coleman, C.M.; Janjic, J.M.; Iyer, P.S.; Fodor, M.D.; Shafer, Y. A. Stephenson, C.R. J.; Kendall, C.; Day, B.W. “Microwave-Assisted “Libraries from Libraries” Approach toward the Synthesis of Allyl- and C-Cyclopropylalkylamides,” Journal of Combinatorial Chemistry 2005, 7, 322-330.
56. Poloyac, S.M.; Rohan, L.C.; Janjic, J.M.; Gibbs, R.B.; Kroboth, P.D.; Smith, R.B.; “GEAR-UP (Graduate Education And Research at the University of Pittsburgh), A Program for Educating Students about Pharmaceutical Research,” American Journal of Pharmaceutical Education 2005, 69, 91-97.  (co-wrote the paper, co-designed the study, served on the organizational committee of the program 2001-2004)
57. Janjic, J.M.; Mu, Y. ; Kendall, C.; Stephenson, C.R. J.; Balachandran, R.; Raccor, B. S. ; Lu, Y.; Zhu, G.; Xie, W.; Wipf, P.; Day, B. W. “New Antiestrogens from a Library Screen of Homoallylic Amides, Allylic Amides and C-Cyclopropylalkylamides,” Bioorganic and Medicinal Chemistry 2005, 13, 157-164.
58. Wipf, P.; Janjic, J.M.; Stephenson, C.R. “Microwave-assisted synthesis of allylic amines: considerable rate acceleration in the hydrozirconation-transmetalation-aldimine addition sequence,” Organic and Biomolecular Chemistry 2004, 2, 443-445. 
59. Lu, G.; Janjic, B.M.; Janjic, J.; Whiteside, T.L.; Storkus, W.J.; Vujanovic, N.L. “Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha(1), -beta(2), Fas ligand, and TNF-related apoptosis-inducing ligand,” Journal of Immunology 2002, 168, 1831-1839.

Book Chapters

1. Jelena M. Janjic* , Riddhi Vichare and Sravan K. Patel “Perfluorocarbon Theranostic Nanoemulsions – From Imaging to Treatment of Inflammatory Diseases and Pain” book chapter in the 2^nd edition of the book titled: Fluorine Magnetic Resonance Imaging Edited by Ulrich Flögel & Eric Ahrens, invited by the editors – 2023, in press
2. JM Janjic*, M Balogh, SKR Adena, A Fitzpatrick, JA Pollock, VS Gorantla, AJ Shepherd*, Chapter 6: “Targeted Imaging and Therapeutic Technologies in Neuroregeneration” in Book: Reconstructive Transplantation and Regenerative Medicine edited by Gorantla, Janjic and Zor; Published by CRC Press 2021, Nov 11^th
3. Meng* and J.M. Janjic Book chapter “Principles of Nanomedicine ” in book titled: Nanomedicine for Inflammatory Diseases edited by Lara Sheherazade Milane and Mansoor M. Amiji, invited by the editors, 2017 Nanomedicine for Inflammatory Diseases, 39-66
4. J.M. Janjic* and S.K. Patel “Perfluorocarbon Theranostic Nanomedicines: Pharmaceutical Scientist’s Perspective” book chapter in book titled: Fluorine Magnetic Resonance Imaging Edited by Ulrich Flögel & Eric Ahrens, invited by the editors, Pan Stanford Publishing Pte. Ltd. 2016 DOI: 10.1201/9781315364605-15
5. J.M. Janjic*, S.K. Patel, C. Bagia “Utilization of Near-Infrared Fluorescent Imaging for Pharmaceutically Relevant Applications” Book chapter in 2016 In Vivo Fluorescence Imaging: Methods and Protocols, 97-108, edited by Mingfeng Bai, PhD, Springer New York 2016 DOI: 10.1007/978-1-4939-3721-9_10, invited by the editors
6. J.M. Janjic and M. Bai “Design and Development of Theranostic Nanomedicines” Chapter in: Nanotechnology for Biomedical Imaging and Diagnostics: From Nanoparticle Design to Clinical Applications, Edited by Mikhail Berezin, John Wiley & Sons, Inc; 2014, invited by the editors

Research Grants

2020–2024
CDMRP PRMRP
W81XWH-19-PRMRP-IIRA
PR190996
Project Title: Neuro-Immuno Modulating Analgesic (NiMA) Nanomedicine Platform for Treatment of Diabetic Neuropathy
Role: Initiating PI (partner PI option) 

2020–2024
W81XWH-19-DMRDP-CRMRP-RESTORE
DM190725
Project Title: Long-Acting Non-Opioid Analgesic (LANA) Nanomedicine for Rapid, Single Dose, Sustained Pain Control and Rehabilitation Support After Neuromusculoskeletal Injury
Role: PI

2020–2024
W81XWH-19-RTRP-IIRA
RT190005
Project Title: Nanoimaging for Noninvasive Monitoring of Donor and Recipient Immune System Contribution to Acute and Chronic Rejection in VCA
Role: Initiating PI (Partner PI Option)

2020–2024
CDMRP RTRP W81XWH-19-PRMRP-IIRA
PR192091
Project Title: “Novel Graft-Implanted Macrophage-Targeted Nanoemulgels for In Situ Immunosuppression in Vascularized Composite Allotransplantation”
Role: Subaward PI

2020–2023
CDMRP W81XWH-19-S-CCC1
DM190271
Project Title: Salvage, Preservation, and Advanced Resuscitation Through Endothelial Stabilization (SPARES)
Role: Subaward PI

2020–2023
AFMSA Program (Intramural)
Project Title: Title: Semi-Autonomous Battlefield Resuscitation and Evacuation (SABRE)/Nano-Emulsion Oxygen Carrier for Advanced Resuscitation and Evacuation (NEOCARE) Phase I and II
Role: PI (Extramural)

2020–2023
AFMSA Program (Intramural)
Project Title: AMENDER Program - Phase I and II
Role: Principal Investigator (Extramural)

2019–2023
CDMRP RTRP
W81XWH-18-RTRP-IIRA
RT180093P1
Project Title: A Graft Implanted Macrophage-Enzyme Responsive Immunosuppressive Therapy (MERIT) to Prevent Chronic Rejection in Vascularized Composite Allotransplantation
Role: Partnering PI

Completed Projects

2021–2022
NAMRU Program (Intramural)
Project Title: Nanomedicine Base Treatment of Standard and Stress Exacerbated Dental Pain
Supporting Agency: USA Navy, NAMRU
Performance Period: 08/01/2021-08/31/2022
Role: Extramural PI

2017–2020
AFMSA
FA8650-17-2-6836 (Intramural)
Project Title: A Targeted, Local, Non-Opioid Therapeutic Strategy for Mitigation, Modulation, and Management of Trauma Induced Neuropathic Pain
Role: PI (Extramural)

2016–2019
NIH
R21EB023104-01
National Institute of Biomedical Engineering and Imaging
Project Title: “Multimodal (PET/MR/NIR) imaging supported drug delivery in inflammatory diseases”
Role: PI (MPI)

2015–2018
NIH R21DA039621-01
National Institute on Drug Abuse
Project Title: “Theranostic Pain Nanomedicines: imaging inflammation, reducing pain and need for opioids.”
Role: PI

2017–2018
Pennsylvania State Health Formula Research Grants Program (C.U.R.E. Award)
Project Title: “Investigation of the molecular basis of neuroinflammatory pain associated with cancer and cancer therapy; an exploration guided by nanotechnology”
Role: Co-Investigator 

2016–2017
Leach Fund Award
Project Title: “An Innovative Anti-inflammatory Treatment for Duchenne Muscular Dystrophy”
Role: Co-Investigator

2016–2017 Leach Fund Award
Project Title: “Investigation of the molecular basis of neuroinflammatory pain with nanotechnology; a potential therapy for chronic pain in animals and people”
Role: Co-Investigator

*2014–2017
The Provost’s Office Interdisciplinary Research Consortia Seed Funds
For the support of the Chronic Pain Research Consortium at Duquesne University
Role: Founder and Co-Director (Award Co-PI) 

2014
N00014-14-1-0723
Office of Naval Research
Project Title: Acquisition of a shear rheometer for research on tissue scaffold ECM hydrogels and other biomaterials
Role: Co-Investigator

2011–2014
1R15AI081218-01A2
NIH, NIAID (National Institute of Allergy and Infectious Diseases)
Project Title: “Non-viral Genetic Modification of Antigen-presenting Cells in Allografts”
Role: Co-Investigator

2011–2013
Pittsburgh Tissue Engineering Initiative Interface Seed Grant Fund
Project Title: “Acute to Chronic Pain Transition in Postsurgical Recovery: Combined input from immune system and peripheral nervous system”  
Role: Partnering PI

2011–2013
Pennsylvania State Health Formula Research Grants Program (C.U.R.E. Award)
Project Title: “From Insoluble Perfluorocarbon Oils to Multifunctional Nanoparticles for Breast Cancer Imaging and Treatment”
Role: PI

*2010–2012
Faculty Development Funds, Duquesne University
Project Title: “Perfluorocarbon nanoemulsions for simultaneous delivery of COX2 inhibitor and antiproliferative agents to breast tumors”
Role: PI

2009–2010
STTR, 1R41EB009618 - 01A1
NIH, NIBIB (National Institute of Biomedical Imaging and Bioengineering)
Project Title: “Dual Mode Nanoemulsions for ¹⁹F MRI and Fluorescence Detection”
Role: PI

Early Career Participation on Extramural Funded Grants

2008–2013
5P41EB001977-22
NMR Center Grant
Project Title: “A MULTIDISCIPLINARY NMR CENTER FOR BIOMEDICAL RESEARCH”
Role: Investigator

2006–2007
1R21NS056998-01
NIH, NINDS (National Institute of Neurological Disorders and Stroke)
Project Title: “Assay Development for Identification of ER-NFkB Pathway Selective Agents”
Role: Research Associate

2004–2005
BC030739
Department of Defense Breast Cancer Research Program
Project Title: “Design, Synthesis and Biological Evaluation of Focused Combinatorial Libraries of Antiestrogens” Pre-doctoral Fellowship
Role: PI

Teaching Portfolio: Pharmaceutics, Pharmaceutical Manufacturing, Molecular Imaging, Drug Delivery, Pharmacology, Medicinal Chemistry, Physiology and Pathophysiology

Graduate Courses Taught (2009–Present)

Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, PA

GPSC 503
Pharmaceutical Unit Operations and Formulation (2 credits/team taught, 3 cr. Course, course-master). Formulation and manufacturing of liquids and semisolids

GPSC 508
Pharmaceutical Manufacturing Laboratory (2 credits/team taught, 3 cr. Course, course-master).  Formulation and manufacturing of liquids and semisolids, team project leader, experimental design,

GPSC 513
Principles of Drug Action, Design, and Delivery (course-master, 1.5 credit/team taught/course master, 3 cr. course).  Medicinal chemistry section and drug discovery

GPSC 617
Pharmaceutical Biotechnology (0.5 credit/team taught, 2 cr. course).  Design of imaging reagents

GPSC 619
Drug Delivery Systems (course master, 2 cr. course).  Drug delivery vehicle design and targeting, focus on cancer therapeutics, theranostics, imaging agents, Bio-design and product development.

         
Pharm.D. Courses Taught (2007–Present)

School of Pharmacy, Duquesne University, Pittsburgh, PA

PHCE  360 / PHCE 360R
Pharmaceutical Principles and Drug Delivery Systems I  (1 credit/team taught, 3 cr. course); with recitation

PHBM 355
Human Physiology and Pathophysiology I (course-master, 1.5 credits/team taught, 4 cr. course).  Chemistry of life, basic biochemical topics in genetics and pharmacogenetics, genetic diseases

PHBM 442
Biomedical Sciences and Therapeutics: Gastroenterology (0.7 credits/team taught, 3 cr. course).  Gastrointestinal disorder therapeutics (medicinal chemistry) and pharmacology

PHBM 442-72
Biomedical Sciences and Therapeutics: Gastroenterology (0.7 credits/team taught, 3 cr. course).  Gastrointestinal disorder therapeutics (medicinal chemistry) and pharmacology 

BMST 426-71
Biomedical Sciences & Therapeutics: Infectious Disease (2 credits/team taught, 3 cr. course).  Medicinal chemistry of infectious disease drugs

BMST 425-71
Biomedical Sciences & Therapeutics:  Endocrine/Nutrition (1 credit/team taught, 3 cr. course).  Medicinal chemistry of steroid and hormonal drugs

PHBM 435
Biomedical Sciences & Therapeutics:  Pain, Musculoskeletal, and Connective Tissue Disorders (0.2 credit/team taught, 2 cr. course).

PHPR-427-61 / UPNS-491-61  
Etiology, Assessment and Treatment of Pain for the Health Care Professional (0.5 credit/team taught, 2 cr. course).  Medicinal chemistry of analgesics, inflammation and pain, mindfulness/meditation in pain management.  Cross- disciplinary course offered through School of Nursing and School of Pharmacy                 

School of Pharmacy, University of Pittsburgh, Pittsburgh, PA   (2001–2004)                                                       

PHARM 5318
Endocrinology, (guest lecturer, 3 cr. course).  Lectures and practicum on steroid hormones, estrogens, SERMs and breast cancer

 

Professional Service

2023	Scientific Program Committee, International Society of Vascularized Composite Allotransplantation International Meeting Dec 1-3, 2023, Loss Angeles, CA.
2022-2024	Council and board member, International Society of Vascularized Composite Allotransplantation (elected in 2022)
2022-2024	At-Large Representative Transplant Regenerative Medicine Community of Practice (TRMCOP) Committee, American Society for Transplantation
2019	Guest Editor, Molecules, Special Issue "Targeted and Personalized Nanomedicines"
2019	Guest Co- Editor (with V.S. Gorantla, WFIRM, guest editor), Nanomedicine, Special focus issue on the topic 'Nanomedicine in Organ Transplantation and Regenerative Surgery - Advances, Applications, and Future Directions'
2019	External advisory board member, Cellular Approaches to Tissue Engineering and Regeneration (CATER) training program, University of Pittsburgh, Pittsburgh, PA
2018–19	Organizing committee member, McGowan Institute of Regenerative Medicine Scientific Retreat/ Session organizer/chair on 3 symposiums: Event held on March 11-12, 2019, UPITT University Club, Pittsburgh, PA

 

University, School, or Department Service

Duquesne University

2023	LGBTQ+ University Committee Member, Duquesne University (volunteered)
2022	2022 Faculty Awards for Excellence Committee, Duquesne University
2011–Present	Founder and Co-Director of Chronic Pain Research Consortium, Duquesne University
2016–Present	Women in Science @Duquesne University, founding committee member
2018	Organizer of DOD Funding workshop for faculty, staff and students - cosponsored by CPRC and WIS of Duquesne University
2017	Hosted and organized the Exhibit Booth for Chronic Pain Research Consortium at the at American Pain Society Scientific Meeting, Pittsburgh, PA, May 2017
2017	Truth, Racial Healing and Transformation Center, led by Darlene Weaver - planning committee member (volunteered)
2016	Chair and facilitator for symposia and events of 2016 Chronic Pain Research Consortium Retreat - 5th Anniversary Celebration, Duquesne University
2016–18	Faculty advisor for Veterans Engagement Consortium
2017–Present	Women in Science Mentoring subcommittee chair
2016, 2017	Day of Learning and Speaking Out (DLSO) held on March 22, 2016 - Organizing committee member
2012–15	Inspired Teaching Retreat with the Center for Teaching Excellence (Co-organizer, dialogue group leader, presenter)
2014–Present	Member, dialogue participant and workshop panelist at the events of Spiritan Pedagogy movement led by Dr. Darlene Weaver
2012	CTE faculty workshop presenter and discussion leader
2011–15	Chronic Pain Research Consortium Research Retreats (Leading organizer)

 

School of Pharmacy and Graduate School of Pharmaceutical Sciences

2022	Duquesne University School of Pharmacy Promotion and Tenure Committee member
2019-2020	School of Pharmacy Faculty Development Committee
2019-Present	School of Pharmacy Tenure and Promotion Committee
2018-2020	Pharmaceutics Discipline representative on the Seminar Series organizing committee
2016–18	Pharmaceutics Discipline faculty coordinator
2016–Present	Faculty development committee
2016–17	Biomedical Sciences Journal Club (founding organizer, shared with Dr. Manickam)
2014–Present	Committee for Faculty Development (Member, appointed by the Dean)
2010–16	Graduate Council (Member, appointed by the Dean)
2010–11	Division of Pharmaceutical Sciences Seminar Series Committee (Chair)
2012–Present	Division of Pharmaceutical Sciences Seminar Series Committee (Discipline representative)
2013, 2015, 2017	AAPS Research Symposium poster and podium presentations Judge
2012, 2016	Oral Research Proposal Defense workshop for graduate students (leader and/or organizer)
2012	Medicinal Chemistry Faculty Search Committee (Member)
2011–12	ACPE Self-Study Faculty and Staff Subcommittee (Member)
2011–12	ACPE Self-Study Graduate Student Subcommittee (Member)
2011	Workgroup-Mentoring Program for Students, Faculty and Staff (Member)
2010	BMS PharmD Curricular Workgroup (Member)
2010–11	Original Research Proposal Defense Workshop for Graduate Students (Leader)
2010	Summer pharmaceutics research journal club (Organizer)

 

University of Pittsburgh

2001–05	Graduate Education and Research at the University of Pittsburgh (GEAR-UP) Program (Organizational Committee Member)
2003–04	Graduate Student Organization, School of Pharmacy (President)
2002	School of Pharmacy Dean Search Committee (Graduate Student Representative)
2002–03	Graduate Student Organization, School of Pharmacy (Vice-President)

 

Service Focused on Promoting Wellness and Wellbeing

2016–18	Mindful Mondays, ongoing practice workshop for scientists, students, faculty and staff started in the Fall 2016 (founder/facilitator).
2014–Present	Student wellness mini-workshops in Living/Learning Centers
2013–14	Student Coping Skills Workgroup in School of Pharmacy (Co-chair)
2014	Wellness seminar on mindfulness and stress reduction in the pharmacy pre-professional program (co-developer and presenter)
2014–15	"Contemplative Scientist" weekly dialogue group for researchers (leader, founder)
2013–14	Mindfulness in daily life/learning discussion leader with RAs in Living/Learning Centers
2011–Present	"Dr. J's De-Stressor" resource folder in blackboard sites in PharmD and graduate courses - live discussions on stress reduction in graduate school life
2011–12	"Skeptic's guide to stress reduction and meditation" presented at faculty meetings and to graduate students

 

Peer Review for Grants

2023	CDMRP PRMRP FP-BP Panel reviewer
2023	NINDS ZNS1 SRB V(01) Special Emphasis Panel HEAL (RFA-NS-21-010)
2022	NIH, NINDS ZNS1 G45 Special Emphasis Panel reviewer
2022	CDMRP, Chronic Pain Research Program, Panel Chair
2021	CDMRP, PRMRP reviewer
2020	NIBIB R01 add hoc reviewer
2020	NHLBI Catalyze Program
2019	NCI Innovative Research in Cancer Nanotechnology
2019	AAAS Reviews
2016, 2017, 2018	NIDA CEBRA R21 study section (Served 5 times)
2017	NIBIB CMIP Study section (ad hoc)
2016	NIH Special panel applications reviewer
2013–15	Grant reviewer for Prostate Cancer Foundation UK
2013	Grant reviewer for Polish Academy of Sciences
2011	Grant reviewer for Duquesne University Faculty Development Fund

 

Invited Peer Review for Scholarly Publications

2020	Reviewer for Nature Chemistry
2018–19	Reviewer for Nanoscale
2015–17	Reviewer for Molecular Pharmaceutics
2014	Reviewer for Food and Function
2014–16	Reviewer for Journal of American Chemical Society
2014	Reviewer for Nature Chemistry
2014	Reviewer for The Journal of Neuroscience
2014	Reviewer for ChemPhysChem
2014	Reviewer for Chemical Science
2014	Reviewer for PLOS One
2013, 2014	Reviewer for World Molecular Imaging Congress abstracts submissions
2013	Reviewer for Nanomedicine
2013	Reviewer for Small
2013, 2015	Reviewer for International Journal of Pharmaceutics
2013	Reviewer for Journal of Materials Chemistry
2012	Reviewer for ChemMedChem
2011–15	Reviewer for Advanced Functional Materials
2010	Reviewer for ACS Medicinal Chemistry Letters
2010–15	Reviewer for Journal of Pharmaceutical Innovation

 

Community Service

2016, 2017, 2018	Science and cultural mini workshops in Mt. Lebanon Extended Day Program
2015	Volunteering in select school events at Markham Elementary School
2014	Fundraising for Serbian Flood Relief (Raised monetary funds and goods)
2011–12	Walk for the Cure (Susan G Komen Breast Cancer Foundation) (Raised funds for Pittsburgh affiliate of Susan G. Komen)
2010	Juvenile Diabetes Research Foundation Walk

2023	American Transplant Society  (ATC)
2023	US Association for the Study of Pain (USASP)
2021–2022	World Molecular Imaging Society
2017–Present	International Society of Vascularized Composite Allotransplantation (ISVCA) Allotransplantation (by invitation), Council member since 2022
2017–Present	The Transplantation Society (TTS)
2014–2019	American Pain Society, member (Membership committee member)
2013–2019	The International Society for Optics and Photonics (SPIE)
2013–2016	The Association for Contemplative Mind in Higher Education
2011–2018	International Association for the Study of PAIN
2009–2012	American Association of Colleges of Pharmacy
2008–Present	American Chemical Society, Fluorine Division
2002–Present	American Association of Pharmaceutical Scientists
2002–2004	American Chemical Society, Medicinal Chemistry Division

Duquesne University, School of Pharmacy
Principal Investigator/Laboratory Director: Jelena M. Janjic, PhD “Dr.J”

NML Capabilities
Nanomedicine produced at NML includes colloidal nanosystems for molecular imaging (magnetic resonance imaging (MRI) and near-infrared fluorescence (NIRF) imaging), targeted and local drug delivery, and imaging-supported drug delivery or theranostic nanomedicines. These products can be delivered locally, parenterally, or implanted into body cavities or wounds. Nanotechnology-based therapeutics are typically presented with high costs and challenging quality control, representing critical barriers to future clinical translation. In contrast, the offeror NML efforts over the past decade produced cost-effective, robust, and scalable manufacturing methods for nanomedicines with a high level of quality control by utilizing Quality-by-Design (QbD) approaches. Specifically, the application of QbD to nanomedicine manufacturing and quality control led to several firsts: 1) the first imaging-supported pain nanomedicine for trauma and surgical pain; 2) the first oxygen carrier with embedded imaging agents for real-time in line tracking during organ/limb preservation; 3) the first successful longitudinal immunomonitoring in non-human primates and porcine models using clinical grade imagers; 4) demonstrated nerve injury recovery following trauma by local nanomedicine implantation in rodents. Furthermore, NML successfully scaled up their laboratory protocols to produce >2L of nanoparticles/batch and evaluate them in human limb trials for oxygen delivery. The work in these areas has been supported by USAF and CDMRP contracts, which are highly collaborative and involve partners across academia, industry and Government. The level of funding NML achieved so far across multiple projects exceeds 6 million dollars for Duquesne University site. Summary of NML research areas is shown in the scheme below:



NML Active DoD contracts 

AFMSA contracts:
FA8650-20-C-6215
FA8650-20-2-6224 

CDMRP contracts:
W81XWH-19-1-0828
W81XWH-20-1-0276
W81XWH-20-1-0730
W81XWH-20-2-0024
W81XWH-20-1-0854             
W81XWH-20-1-0769
W81XWH-21-1-0197             

Laboratory Space, Equipment and Resources

The total laboratory space is 2094 sq. feet: the primary laboratory space of 560 sq. ft. (401 Mellon Hall),  500 sq.ft. (403 Mellon Hall), 514 sq. ft (418F Mellon Hall) and 520 sq. ft. (427 Mellon Hall). NML has 4 chemical hoods, 2 biosafety sterile work hoods, liquid nitrogen and -80 freezers and lyophilizers. The labs have designated areas for analytical work for nanomaterials analyses including: 2 state-of-the-art particle size Zetasizer Nano Instruments (Malvern UK), dedicated HPLC and Rheometers. The lab has four microfluidizer units, sonicators, planetary mixers and centrifuges. The lab has several microscopes, designated incubators and total of 6 refrigerators. The lab has access to state of the art LCMS and NMR facilities in Mellon Hall, as well as confocal microscopes, small animal facility, NIRF imagers (preclinical and clinical) and other resources needed for running preclinical studies of produced nanomaterials.