Yunbo Li

Dr. Li received his MD & MPH from Shandong Medical University & Shandong Academy of Medical Sciences, and PhD from Johns Hopkins University. He completed postdoctoral fellowships at Johns Hopkins University and University of California at Berkeley/Lawrence Berkeley National Laboratory.

He joined Duquesne University College of Osteopathic Medicine in June 2024 following his 18 years of tenure as professor and chair of pharmacology at VCOM/Virginia Tech CRC (2006 to 2012) and Campbell University SOM (2013 to 2024).

Dr. Li has published 149 journal articles in the field of biomedicine, and written several books, including “Cardiovascular Diseases: From Molecular Pharmacology to Evidence-Based Therapeutics (Wiley)”, “Free Radical Biomedicine: Principles, Clinical Correlations, and Methodologies (Bentham)”, and “Biomedical Research: Strategic Planning for Success (Nova)”. The research in his laboratory has been funded by the National Institutes of Health (NIH) (NCI, NHLBI, NIDDK, & NIGMS; R01s, R21, R15s). Li had served on several NIH grants (R01/R21) review panels and as an ad-hoc reviewer for grants from multiple entities, including Johns Hopkins University Center for Environmental Health Sciences and the National Science Foundation (NSF).

In addition to his research career, Dr. Li has over two decades of teaching experience in biomedical sciences.

• MD & MPH, Shandong Medical University & Shandong Academy of Medical Sciences
• PhD, Johns Hopkins University.

• Oxidative and inflammatory stress in disease process

• Shukla H, Chitrakar R, Bibi HA, Gaje G, Koucheki A, Trush MA, Zhu H, Li YR, Jia Z. Reactive oxygen species production by BP-1,6-quinone and its effects on the endothelial dysfunction: involvement of the mitochondria. Toxicol Lett 2020; 322:120–130. https://dx.doi.org/10.1016/j.toxlet.2020.01.011
• Shukla H, Gaje G, Koucheki A, Lee H, SunX, Trush MA, Zhu H, Li YR, Jia Z. NADPH-quinone oxidoreductase-1 mediates benzo-[a]-pyrene-1,6-quinone-induced cytotoxicity and reactive oxygen species production in human EA.hy926 endothelial cells. Toxicol Appl Pharmacol 2020; 404:115180. https://dx.doi.org/10.1016/j.taap.2020.115180
• Shukla H, Lee H, Koucheki A, Bibi H, Gaje G, Sun X, Zhu H, Li YR, Jia Z. Targeting glutathione with the triterpenoid CDDO-Im protects against benzo-a-pyrene-1,6-quinone-induced cytotoxicity in endothelial cells. Mol Cell Biochem 2020;474(1–2):27–39. https://dx.doi.org/10.1007/s11010-020-03831-6
• Li YR, Zhu H, Danelisen I. Role of peroxiredoxins in protecting against cardiovascular and related disorders. Cardiovasc Toxicol 2020; 20(5):448–453. https://dx.doi.org/10.1007/s12012-020-09588-0
• Khan S, Chavez J, Zhu X, Chiu NH, Zhang W, Yin Z, Han H, Yang J, Sigler R, Tian S, Zhu H, Li Y, Wei J, Yi X, Jia Z. Carbon nanodots inhibit oxidized low-density lipoprotein-induced injury and monocyte adhesion to endothelial cells through scavenging reactive oxygen species. J Biomed Nanotechnol 2021; 17(8):1654–1667. https://dx.doi.org/10.1166/jbn.2021.3125
• Li YR, Zhu H. Vitamin C for sepsis intervention: from redox biochemistry to clinical medicine. Mol Cell Biochem 2021; 476(12):4449–4460. https://dx.doi.org/10.1007/s11010-021-04240-z
• Li YR, Zhu H. Nanoceria potently reduce superoxide fluxes from mitochondrial electron transport chain and plasma membrane NADPH oxidase in human macrophages. Mol Cell Biochem 2021; 476(12):4461–4470. https://dx.doi.org/10.1007/s11010-021-04246-7
• Ahmed H, Amin U, Sun X, Pitts D, Li Y, Zhu H,  Jia Z. Triterpenoid CDDO-Im protects against lipopolysaccharide-induced inflammatory response and cytotoxicity in macrophages: the involvement of the NF-κB signaling pathway. Exp Biol Med 2022; 247(8): 683–690. https://dx.doi.org/10.1177/15353702211066912
• Gaje G, Legins J, Rispress J, Li YR, Zhu H, Jia Z. 3H-1,2-Dithiole-3-thione reduces lipopolysaccharide-induced liver and kidney inflammation in C57BL/6 Mice. EC Pharmacol Toxicol 2022; 10(1):28–36. https://ecronicon.net/assets/ecpt/pdf/ECPT-10-00689.pdf
• Zhu H, Bu A, Santo A, Li YR. 3H-1,2-Dithiole-3-thione suppresses LPS-induced proinflammatory responses in macrophages: potential involvement of antioxidant induction, NF-κB, and Nrf2. Mol Cell Biochem 2022; 477:1499–1506. https://dx.doi.org/10.1007/s11010-021-04331-x
• Zhu H, Jia Z, Li YR, Danelisen I. Molecular mechanisms of action of metformin: latest advances and therapeutic implications. Clin Exp Med 2023; Apr 4;1-11. https://dx.doi.org/10.1007/s10238-023-01051-y
• Li JZ, Li YR. Cardiovascular protection by metformin: latest advances in basic and clinical research. Cardiology 2023;148(4):374-384. https://dx.doi.org/10.1159/000531432
• Li YR, Traore K, Zhu H. Novel molecular mechanisms of doxorubicin cardiotoxicity: latest leading-edge advances and clinical implications. Mol Cell Biochem 2024 May;479(5):1121-1132. https://dx.doi.org/10.1007/s11010-023-04783-3
•  Li YR. Vitamin C in Health and Disease: From Redox Biology to Clinical Medicine. In: Shah AK, Tappia PS, Dhalla NS (eds) Hydrophilic Vitamins in Health and Disease. Advances in Biochemistry in Health and Disease, 2024; Vol 29, pp. 341-355. Springer Nature, Switzerland. https://doi.org/10.1007/978-3-031-55474-2_16
• Li YR. Cellular Antioxidants and Phase 2 Proteins. In: F.A. Villamena FA, Forman HJ (eds) Molecular Basis of Oxidative Stress: Chemistry, Toxicology, Disease Pathogenesis, Diagnosis, and Therapeutics, 2nd edition, Wiley-Blackwell, New Jersey, 2024 (in press).